Hydrochloric Acid → 6-(4-Methylpiperazin-1-yl)pyridine-3-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

A solution of 6-(4-methyl-piperazin-1-yl)-nicotinic acid methyl ester (5.56 g) in MeOH/H2O 1:1 (100 ml) was cooled to 0° C. and treated with NaOH (1.9 g). The reaction mixture was stirred for 45 min at 0° C. and for 5 hrs at r.t., then neutralized with 1N HCl and concentrated. The crude product was used in the next reaction step without further purification.

Provenance & Evidence