Benzylamine → HCID 57571682, compound

HRID 1677102Notes

Reaction equation

HRID 1677102 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:30])[NH:21][CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26]C=3)=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(N1CCNCC1)(OC(C)(C)C)=O.C(N)C1C=CC=CC=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:30])[NH:21][CH2:22][C:23]3[CH:24]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:16][N:15]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

4

Reactant 3

HCID 7504BenzylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 66995381HCID 66995381, compound

Product 1

HCID 57571682HCID 57571682, compound

Procedure

In analogy to example 1 4-(5-phenethylcarbamoyl-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester was prepared starting from N-Boc-piperazine and using benzylamine in the last coupling step. Light yellow solid. MS (ISP): 397.5 ([M+H]+)

Sources & evidence

ORD record
ord-bd15c549c4ba4c6e8ae87c6188c90e8c
Source dataset
uspto-grants-2011_08
Patent number
US08008305B2

Reaction notes

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