HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 6-Morpholin-4-yl-N-[2-(4-phenoxy-phenyl)-ethyl]-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Reactant | 4-Phenoxyphenethylamine | HCID 145535 | — |
| Reactant | 6-chloro-N-[2-(4-phenoxy-phenyl)-ethyl]-nicotinamide | HCID 86626966 | — |
| Product | 6-Morpholin-4-yl-N-[2-(4-phenoxy-phenyl)-ethyl]-nicotinamide | HCID 57571699 | — |
Reaction Steps
In analogy to example 21 6-chloro-nicotinic acid was coupled with 4-phenoxyphenethylamine. The intermediate 6-chloro-N-[2-(4-phenoxy-phenyl)-ethyl]-nicotinamide was reacted with morpholine. White solid. MS (ISP): 404.6 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008305B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-bf35b22eb5a444b1b829341362090fe9 |
| Source note | uspto-grants-2011_08 |