HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorobenzoic Acid → Rac-n-[1-(3,4-dichloro-phenyl)-ethyl]-3-fluoro-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorobenzoic Acid | HCID 9968 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-(3,4-dichlorophenyl)ethanamine | HCID 3159242 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Rac-n-[1-(3,4-dichloro-phenyl)-ethyl]-3-fluoro-benzamide | HCID 24396994 | — |
Reaction Steps
To a solution of 143.8 mg (0.75 mmol) N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC.HCl) and 91.6 mg (0.75 mmol) 4-dimethylaminopyridine (DMAP) in 1.5 ml dichloromethane were added 142 mg (0.75 mmol) rac-1-(3,4-dichloro-phenyl)-ethylamine and the solution stirred at ambient temperature for 5 min. To this solution were added 70 mg (0.5 mmol) 3-fluoro-benzoic acid and the mixture stirred at ambient temperature for 5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008305B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-6adb2804bd084203a37132ff66fd7bdd |
| Source note | uspto-grants-2011_08 |