4-Phenoxyphenethylamine → HCID 57571702, compound

HRID 1677117Notes

Reaction equation

HRID 1677117 reaction equation
CO[C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][C:5]=1Cl.[CH3:12][S:13]([N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)(=[O:15])=[O:14].[O:22]([C:29]1[CH:34]=[CH:33][C:32]([CH2:35][CH2:36][NH2:37])=[CH:31][CH:30]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH3:12][S:13]([N:16]1[CH2:21][CH2:20][N:19]([C:5]2[N:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([NH:37][CH2:36][CH2:35][C:32]2[CH:33]=[CH:34][C:29]([O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:30][CH:31]=2)=[O:11])[CH2:18][CH2:17]1)(=[O:15])=[O:14]

Participants

4

Reactant 3

HCID 1455354-PhenoxyphenethylamineHCID 7091611-(Methylsulfonyl)piperazineHCID 819931Methyl 2-chloronicotinate

Product 1

HCID 57571702HCID 57571702, compound

Procedure

The title compound was prepared in analogy to example 1, but starting from 2-chloro-nicotinic acid methyl ester and subsequently using 1-methanesulfonyl-piperazine in the first step and 2-(4-phenoxy-phenyl)-ethylamine in the third step. MS (ISP): 481.1 ((M+H)+.).

Sources & evidence

ORD record
ord-26225b4f318d410bb451ea08700a10ea
Source dataset
uspto-grants-2011_08
Patent number
US08008305B2

Reaction notes

Loading…