2-(Trifluoromethyl)aniline → HCID 178471912, compound

Participants

Reaction Steps

To a solution of ethyl 2-benzoyl-3-ethoxyacrylate (3.70 g, 14.9 mmol) in toluene (14.9 mL), 2-trifluoromethylaniline (2.06 mL, 16.4 mmol) was added. After irradiated at 150° C. for 1 hour using a microwave (Biotage® initiator), the reaction solution was concentrated in vacuo. The title compound (5.41 g, yield 99%) was obtained as a cis/trans mixture (1:1) as an orange oil.

Provenance & Evidence