Sodium Hydroxide → HCID 67371312, compound

HRID 1677139Notes

Reaction equation

HRID 1677139 reaction equation
C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16](=[O:18])[CH3:17])=[CH:12][N:11]=2)=[CH:6][CH:5]=1.[OH-].[Na+:21]>O1CCCC1.C(O)C>[Na+:21].[C:16]([C:13]1[CH:14]=[CH:15][C:10]([C:7]2[CH:8]=[CH:9][C:4]([C:3]([O-:19])=[O:2])=[CH:5][CH:6]=2)=[N:11][CH:12]=1)(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57980135HCID 57980135, compound

Product 1

HCID 67371312HCID 67371312, compound

Reagents, catalysts & solvents 1

HCID 21873804Tetrahydrofuran ethanolSolvent

Procedure

Procedure V′: To a stirring solution of 4-(5-acetyl-pyridin-2-yl)-benzoic acid methyl ester (1.0 mmol) in 1:1 tetrahydrofuran/ethanol (0.20M), add 2N sodium hydroxide and heat to reflux for three hours. After this time, concentrate the reaction in vacuo. Rinse the solid with dichloromethane and decant. The title compound, remaining as a solid, requires no further purification. MS (m/e): 242.1 (M+1)

Workup

  1. temperatureheat
  2. temperatureto reflux for three hours
  3. concentrationAfter this time, concentrate
  4. customthe reaction in vacuo
  5. washRinse the solid with dichloromethane
  6. customdecant
  7. customno further purification

Sources & evidence

ORD record
ord-1deadba71f5d4fcba18bd850fb00b9a4
Source dataset
uspto-grants-2011_08
Patent number
US08008301B2

Reaction notes

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