HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 4-Bromo-2-fluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Bromo-2-fluorobenzoic acid | HCID 302681 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Bromo-2-fluorobenzoyl chloride | HCID 2734026 | — |
Reaction Steps
Procedure CC: To a stirring solution of 4-bromo-2-fluorobenzoic acid (1.0 mmol) and oxalyl chloride (2.0 mmol) in dichloromethane (0.10M), add 2 drops of dimethylformamide as a catalyst. Stir at room temperature for 3 hours. After this time, concentrate the reaction in vacuo. Assume total conversion to the acid chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008301B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-fd8355f2101a44f595dffa4d770fde30 |
| Source note | uspto-grants-2011_08 |