2-Pyridinamine, 5-iodo- → [4-(6-Amino-pyridin-3-yl)-phenyl]-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

HRID 1677149Notes

Reaction equation

HRID 1677149 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[N:9]1([CH2:14][C@@H:15]2[CH2:19][CH2:18][CH2:17][N:16]2[C:20]([C:22]2[CH:27]=[CH:26][C:25](B3OC(C)(C)C(C)(C)O3)=[CH:24][CH:23]=2)=[O:21])[CH2:13][CH2:12][CH2:11][CH2:10]1>>[NH2:8][C:5]1[N:6]=[CH:7][C:2]([C:25]2[CH:26]=[CH:27][C:22]([C:20]([N:16]3[CH2:17][CH2:18][CH2:19][C@H:15]3[CH2:14][N:9]3[CH2:10][CH2:11][CH2:12][CH2:13]3)=[O:21])=[CH:23][CH:24]=2)=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 885792-Pyridinamine, 5-iodo-HCID 57980137HCID 57980137, compound

Product 1

HCID 57980103[4-(6-Amino-pyridin-3-yl)-phenyl]-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

Procedure

The title compound is prepared starting with 5-iodo-pyridin-2-ylamine and (2-(S)-Pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone following a procedure significantly analogous to Procedure FF. MS (m/e): 351.2 (M+1)

Sources & evidence

ORD record
ord-012811068664470d9fe8c0c29c3c0690
Source dataset
uspto-grants-2011_08
Patent number
US08008301B2

Reaction notes

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