HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-bromo-2-fluorophenyl)methanesulfonamide → N-[3-Fluoro-4'-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-biphenyl-4-yl]-methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-bromo-2-fluorophenyl)methanesulfonamide | HCID 956286 | — |
| Reactant | HCID 57980137 | HCID 57980137 | — |
| Product | N-[3-Fluoro-4'-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-biphenyl-4-yl]-methanesulfonamide | HCID 57980109 | — |
Reaction Steps
The title compound is prepared starting with (2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone and N-(4-Bromo-2-fluoro-phenyl)-methanesulfonamide following a procedure significantly analogous to Procedure FF. MS (m/e): 446.2 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008301B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-87540b067eab4428bec82a89acd3a62e |
| Source note | uspto-grants-2011_08 |