HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Prolinol → (2-(S)-Hydroxymethyl-pyrrolidin-1-yl)-(4'-trifluoromethyl-biphenyl-4-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Prolinol | HCID 640091 | — |
| Reactant | 4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid | HCID 2782719 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Product | (2-(S)-Hydroxymethyl-pyrrolidin-1-yl)-(4'-trifluoromethyl-biphenyl-4-yl)-methanone | HCID 57980177 | — |
Reaction Steps
The title compound is prepared in a manner substantially analogous to Procedure B′ from 4′-trifluoromethyl-biphenyl-4-carboxylic acid, lithium salt using (S)-2-pyrrolidine methanol as the amine. MS (ES+) 350.2,
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008301B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-18fab55a1a814368b90a94cf37cc2426 |
| Source note | uspto-grants-2011_08 |