4-(Methanesulfonyl)phenylboronic acid → HCID 67372984, compound

HRID 1677161Notes

Reaction equation

HRID 1677161 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH2:13][CH2:12][C@H:11]2[CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:9])=[C:4]([C:21]([F:24])([F:23])[F:22])[CH:3]=1.[CH3:25][S:26]([C:29]1[CH:34]=[CH:33][C:32](B(O)O)=[CH:31][CH:30]=1)(=[O:28])=[O:27]>>[CH3:25][S:26]([C:29]1[CH:34]=[CH:33][C:32]([C:7]2[CH:2]=[CH:3][C:4]([C:21]([F:24])([F:23])[F:22])=[C:5]([C:8]([N:10]3[CH2:14][CH2:13][CH2:12][C@H:11]3[CH2:15][N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)=[O:9])[CH:6]=2)=[CH:31][CH:30]=1)(=[O:28])=[O:27]

Participants

3

Reactant 2

HCID 27343644-(Methanesulfonyl)phenylboronic acidHCID 11965201HCID 11965201, compound

Product 1

HCID 67372984HCID 67372984, compound

Procedure

The title compound is prepared in a manner substantially analogous to Example 14 via Procedure F′ from (4-bromo-2-trifluoromethyl-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 4-methanesulfonylbenzene boronic acid (CAS 149104-88-1). MS (FIA) 481 (MH+)

Sources & evidence

ORD record
ord-c9e5ed1d45154034b379cbe63358776c
Source dataset
uspto-grants-2011_08
Patent number
US08008301B2

Reaction notes

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