4-(Methanesulfonyl)phenylboronic acid → HCID 57980157, compound

HRID 1677163Notes

Reaction equation

HRID 1677163 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]([N:11]2[CH2:15][CH2:14][CH2:13][C@H:12]2[CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:10])=[C:4]([F:22])[CH:3]=1.[CH3:23][S:24]([C:27]1[CH:32]=[CH:31][C:30](B(O)O)=[CH:29][CH:28]=1)(=[O:26])=[O:25]>>[F:22][C:4]1[CH:3]=[C:2]([C:30]2[CH:31]=[CH:32][C:27]([S:24]([CH3:23])(=[O:26])=[O:25])=[CH:28][CH:29]=2)[CH:7]=[C:6]([F:8])[C:5]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][N:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)=[O:10]

Participants

3

Reactant 2

HCID 27343644-(Methanesulfonyl)phenylboronic acidHCID 11965202HCID 11965202, compound

Product 1

HCID 57980157HCID 57980157, compound

Procedure

The title compound is prepared in a manner substantially analogous to Example 14 via Procedure F′ from (4-bromo-2,6-difluoro-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 4-methanesulfonylbenzene boronic acid (CAS 1491 04-88-1). MS (FIA) 489 (MH+)

Sources & evidence

ORD record
ord-c4b812ae8aae46069cfd6f709beb9b12
Source dataset
uspto-grants-2011_08
Patent number
US08008301B2

Reaction notes

Loading…