(Pyridin-4-yl)boronic acid → HCID 57980095, compound

HRID 1677164Notes

Reaction equation

HRID 1677164 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]([N:11]2[CH2:15][CH2:14][CH2:13][C@H:12]2[CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:10])=[C:4]([F:22])[CH:3]=1.[N:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1>>[F:8][C:6]1[CH:7]=[C:2]([C:26]2[CH:27]=[CH:28][N:23]=[CH:24][CH:25]=2)[CH:3]=[C:4]([F:22])[C:5]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][N:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)=[O:10]

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 11965202HCID 11965202, compound

Product 1

HCID 57980095HCID 57980095, compound

Procedure

The title compound is prepared in a manner substantially analogous to Example 14 via Procedure F′ from (4-bromo-2,6-difluoro-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and pyridine-4-boronic acid. MS (FIA) 372 (MH+)

Sources & evidence

ORD record
ord-dd6d802b193145179a956de520c5566f
Source dataset
uspto-grants-2011_08
Patent number
US08008301B2

Reaction notes

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