(2,3-Dihydro-1,4-benzodioxin-6-yl)boronic acid → HCID 57980189, compound

HRID 1677177Notes

Reaction equation

HRID 1677177 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH2:13][CH2:12][C@H:11]2[CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:9])=[C:4]([F:21])[CH:3]=1.[O:22]1[C:27]2[CH:28]=[CH:29][C:30](B(O)O)=[CH:31][C:26]=2[O:25][CH2:24][CH2:23]1>>[O:22]1[C:27]2[CH:28]=[CH:29][C:30]([C:2]3[CH:7]=[CH:6][C:5]([C:8]([N:10]4[CH2:14][CH2:13][CH2:12][C@H:11]4[CH2:15][N:16]4[CH2:20][CH2:19][CH2:18][CH2:17]4)=[O:9])=[C:4]([F:21])[CH:3]=3)=[CH:31][C:26]=2[O:25][CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 2776178(2,3-Dihydro-1,4-benzodioxin-6-yl)boronic acidHCID 11965125(4-Bromo-2-fluoro-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

Product 1

HCID 57980189HCID 57980189, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure SS starting from (4-bromo-2-fluoro-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 2,3-Dihydro-1,4-benzodioxin-6-yl boronic acid. MS (M+H) 411.2

Sources & evidence

ORD record
ord-305442650d674578aaa302453f5743e3
Source dataset
uspto-grants-2011_08
Patent number
US08008301B2

Reaction notes

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