3-(Methylsulfonyl)phenylboronic acid → HCID 57980086, compound

HRID 1677178Notes

Reaction equation

HRID 1677178 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH2:13][CH2:12][C@H:11]2[CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:9])=[C:4]([F:21])[CH:3]=1.[CH3:22][S:23]([C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][CH:31]=1)(=[O:25])=[O:24]>>[F:21][C:4]1[CH:3]=[C:2]([C:30]2[CH:29]=[CH:28][CH:27]=[C:26]([S:23]([CH3:22])(=[O:25])=[O:24])[CH:31]=2)[CH:7]=[CH:6][C:5]=1[C:8]([N:10]1[CH2:14][CH2:13][CH2:12][C@H:11]1[CH2:15][N:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1)=[O:9]

Participants

3

Reactant 2

HCID 27735423-(Methylsulfonyl)phenylboronic acidHCID 11965125(4-Bromo-2-fluoro-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

Product 1

HCID 57980086HCID 57980086, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure SS starting from (4-bromo-2-fluoro-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 3-Methylsulfonyl benzene boronic acid. MS (M+H) 431.1

Sources & evidence

ORD record
ord-3de4b184c15448f9b2b5819493692d00
Source dataset
uspto-grants-2011_08
Patent number
US08008301B2

Reaction notes

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