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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1677180Generated: October 25, 2026

(4-(Methylsulfinyl)phenyl)boronic acid → (3-Fluoro-4'-methanesulfinyl-biphenyl-4-yl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

https://huagongshe.com/reaction/1677180

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-(Methylsulfinyl)phenyl)boronic acidHCID 2773531—
Reactant(4-Bromo-2-fluoro-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanoneHCID 11965125—
Product(3-Fluoro-4'-methanesulfinyl-biphenyl-4-yl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanoneHCID 57980145—

Reaction Steps

The title compound is prepared in a manner substantially analogous to Procedure SS starting from (4-bromo-2-fluoro-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 4-Methylsulfinyl benzene boronic acid. MS (M+H) 415.1

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08008301B2
Source datasetuspto-grants-2011_08
ORD IDord-bc3b3e16165c46a1b2c377a0a916168e
Source noteuspto-grants-2011_08