(6-Methoxypyridin-3-yl)boronic acid → HCID 57980166, compound

HRID 1677183Notes

Reaction equation

HRID 1677183 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH2:13][CH2:12][C@H:11]2[CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:9])=[C:4]([F:21])[CH:3]=1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][N:25]=1>>[F:21][C:4]1[CH:3]=[C:2]([C:27]2[CH:26]=[N:25][C:24]([O:23][CH3:22])=[CH:29][CH:28]=2)[CH:7]=[CH:6][C:5]=1[C:8]([N:10]1[CH2:14][CH2:13][CH2:12][C@H:11]1[CH2:15][N:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1)=[O:9]

Participants

3

Reactant 2

HCID 2734368(6-Methoxypyridin-3-yl)boronic acidHCID 11965125(4-Bromo-2-fluoro-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

Product 1

HCID 57980166HCID 57980166, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure SS starting from (4-bromo-2-fluoro-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 2-Methoxy-5-pyridine boronic acid. MS (M+H) 384.2

Sources & evidence

ORD record
ord-e5b1e76e409548c09d7c3bd7a0dff279
Source dataset
uspto-grants-2011_08
Patent number
US08008301B2

Reaction notes

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