HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 57980091, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Bromo-2-fluorobenzoic acid | HCID 302681 | — |
| Reactant | 4-(Methanesulfonyl)phenylboronic acid | HCID 2734364 | — |
| Reactant | (R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine | HCID 46911921 | — |
| Product | HCID 57980091 | HCID 57980091 | — |
Reaction Steps
The title compound is prepared in a manner substantially analogous to Procedure A′, T′ and B′ starting from 4-bromo-2-fluoro-benzoic acid, 4-methanesulfonylphenyl boronic acid and 2-(R)-Methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (M+H) 445.2. Alternatively, the title compound maybe prepared by methylation of 3′-fluoro-4-[(2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine-1-carbonyl]-biphenyl-4-sulfinic acid using NaH and iodomethane at 0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008301B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-6adaf86c013b4ba386a66337836406a2 |
| Source note | uspto-grants-2011_08 |