HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-2-ethylpyrrolidine → [2-(S)-(2-(R)-Ethyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-(4'-trifluoromethyl-biphenyl-4-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-2-ethylpyrrolidine | HCID 10931375 | — |
| Reactant | (2-(S)-Hydroxymethyl-pyrrolidin-1-yl)-(4'-trifluoromethyl-biphenyl-4-yl)-methanone | HCID 57980177 | — |
| Product | [2-(S)-(2-(R)-Ethyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-(4'-trifluoromethyl-biphenyl-4-yl)-methanone | HCID 57980152 | — |
Reaction Steps
The title compound is prepared in a manner substantially analogous to Procedure RR starting from (2-(S)-hydroxymethyl-pyrrolidin-1-yl)-(4′-trifluoromethyl-biphenyl-4-yl)-methanone and 2-(R)-ethyl-pyrrolidine (CAS 460748-80-5) MS (M+H) 431.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008301B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-7dc877af5726458fb8d28b4605ea67b7 |
| Source note | uspto-grants-2011_08 |