5-Methoxypyridine-3-boronic Acid → HCID 57980156, compound

HRID 1677203Notes

Reaction equation

HRID 1677203 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7](B(O)O)[CH:8]=1.Br[C:13]1[CH:18]=[C:17]([F:19])[C:16]([C:20]([N:22]2[CH2:26][CH2:25][CH2:24][C@H:23]2[CH2:27][N:28]2[CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:21])=[C:15]([F:33])[CH:14]=1>>[F:19][C:17]1[CH:18]=[C:13]([C:7]2[CH:6]=[N:5][CH:4]=[C:3]([O:2][CH3:1])[CH:8]=2)[CH:14]=[C:15]([F:33])[C:16]=1[C:20]([N:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[CH2:27][N:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1)=[O:21]

Participants

3

Reactant 2

HCID 27630875-Methoxypyridine-3-boronic AcidHCID 11965202HCID 11965202, compound

Product 1

HCID 57980156HCID 57980156, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure WW starting from 3-methoxypyridine-5-boronic acid and (4-bromo-2,6-difluoro-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone to give 20 mg (19%). MS (ES+) 402 m/z

Workup

  1. customto give 20 mg (19%)

Sources & evidence

ORD record
ord-d8d931383d894cd08c43aae21d5a1699
Source dataset
uspto-grants-2011_08
Patent number
US08008301B2

Reaction notes

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