(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine → [4-(6-Methoxy-pyridin-2-yl)-phenyl]-[2-(S)-(2-(R)-Methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone

Participants

Reaction Steps

The title compound is prepared in a manner substantially analogous to General Procedure B′ using 4-(6-Methoxy-pyridin-2-yl)-benzoic acid (573 mg, 2.5 mmol) and 2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine (337 mg, 2.0 mmol) to give 580 mg (76% yield). MS (ES+) 380.2 (M+H)+

Provenance & Evidence