Tetrabutylammonium Fluoride → HCID 44208752, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-Methyl-2-(3,4,5-trimethoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide (64 mg) in 0.5 mL of THF was added 400 uL of 1.0 M TBAF in THF. Heated the mixture to 60° C. for 14 h. Diluted with diethyl ether and water and partitioned. The organic phase was washed with brine, dried over Na2SO4, filtered, and concentrated. Flash purification (95:5 methylene chloride:Methanol) afforded 12 mg of 6-Methyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide as a yellow solid.

Provenance & Evidence