Trifluoroacetic acid → HCID 44207663, compound

Participants

Reaction Steps

To a solution of 2-methyl-2-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (18 mg, 0.04 mmol) in anhydrous dichloromethane (3.0 ml) was added trifluoroacetic acid (1.0 ml, 13.5 mmol) dropwise. The reaction mixture was stirred for two days. The reaction mixture was partitioned between EtOAc/saturated aqueous Na2CO3. The organic layers were collected, dried over MgSO4, filtered, and concentrated. The residue was purified by preparative thin layer chromatography using 0.5:9.5:90 concentrated aqueous NH4OH: MeOH: dichloromethane as eluant to provide 10 mg (70%) of (2-methyl-pyrrolidin-2-yl)-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-methanone as a light yellow solid. M+H=397.

Provenance & Evidence