HRID1677395

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22258917

1,1-Dimethylethyl 3-formyl-3-methyl-1-piperidinecarboxylate

C12H21NO3

结构：COc1cc(-c2cnc3c(n2)c(I)cn3[Si](C(C)C)(C(C)C)C(C)C)cc(OC)c1OC

HCID59540525

未命名化合物

PRODUCTS

生成物

结构：COc1cc(-c2cnc3[nH]cc(C(O)C4(C)CCCN(C(=O)OC(C)(C)C)C4)c3n2)cc(OC)c1OC

HCID67345523

未命名化合物

PROCEDURE

实验过程

3-{Hydroxy-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-methyl}-3-methyl-piperidine-1-carboxylic acid tert-butyl ester was prepared starting from 7-iodo-5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine and 3-formyl-3-methyl-piperidine-1-carboxylic acid tert-butyl ester (WO 2002024679) following general procedures as described in these Examples.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-02a2ce6eeda6428b8f1f6dc05deb491f
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08008298B2
来源说明: uspto-grants-2011_08

反应 SMILES

I[C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([C:11]3[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[C:13]([O:21][CH3:22])[CH:12]=3)[N:9]=2)[N:4]([Si](C(C)C)(C(C)C)C(C)C)[CH:3]=1.[C:33]([O:37][C:38]([N:40]1[CH2:45][CH2:44][CH2:43][C:42]([CH:47]=[O:48])([CH3:46])[CH2:41]1)=[O:39])([CH3:36])([CH3:35])[CH3:34]>>[C:33]([O:37][C:38]([N:40]1[CH2:45][CH2:44][CH2:43][C:42]([CH:47]([OH:48])[C:2]2[C:10]3[C:5](=[N:6][CH:7]=[C:8]([C:11]4[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[C:13]([O:21][CH3:22])[CH:12]=4)[N:9]=3)[NH:4][CH:3]=2)([CH3:46])[CH2:41]1)=[O:39])([CH3:36])([CH3:35])[CH3:34]