Potassium Carbonate → HCID 44208751, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-3-methyl-butan-1-one and 1-(2-chloro-5H-pyrrolo[2,3-b]pyrazin-7-yl)-3-methyl-butan-1-one (55 mg), potassium carbonate (95 mg, 0.69 mmol), 3,4,5-trimethoxyphenylboronic acid (47 mg, 0.22 mmol) and Pd(dppf)Cl2-DCM (16 mg, 0.02 mmol) was placed in a 5 ml microwave vial. The vial was capped and purged with nitrogen. Solvent was added (2 ml of 20% aqueous dioxane) and the vial was purged again with nitrogen. The reaction mixture was heated in a microwave reactor at 150° C. for 30 min. The solvents were evaporated and the crude product was purified by flash chromatography using a gradient of 20% ethyl acetate in hexanes up to 50% to yield 30 mg of 3-methyl-1-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-butan-1-one. MS: (M+H)+=370, MP=210.0-211.4° C.

Provenance & Evidence