Methanol → HCID 44192428, compound

Participants

Reaction Steps

A solution of 1-[7-(2,2-Dimethyl-propionyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-3,4-dihydro-1H-quinolin-2-one (0.2562 g, 0.535 mmol) in 2 mL of dichloromethane and 2 mL of trifluoroacetic acid was stirred for 5 h then concentrated to a yellow oil. The oil was dissolved in 2 mL of ethanol and the solution was treated with sodium acetate trihydrate (01.3 g, 9.55 mmol). Silica gel chromatography (0→50% 60:10:1 CH2Cl2:MeOH:NH4OH/dichloromethane) afforded 0.1626 g (87% yield) of 1-[7-(2,2-Dimethyl-propionyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-3,4-dihydro-1H-quinolin-2-one as a yellow solid.

Provenance & Evidence