Methanol → HCID 59540720, compound

Participants

Reaction Steps

A solution of 1-[2-(3-Cyclopentylamino-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one (0.1781 g, 0.361 mmol) in 1 mL of dichloromethane and 1 mL of trifluoroacetic acid was stirred for 3 h then concentrated to a yellow oil. The oil was dissolved in 1 mL of methanol and the solution was treated with potassium hydroxide (0.24 g, 4.34 mmol). Preparative thin layer chromatography (50% 60:10:1 CH2Cl2:MeOH:NH4OH/dichloromethane) afforded 0.070 g (53% yield) of 1-[2-(3-Cyclopentylamino-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one as a yellow solid.

Provenance & Evidence