Methanol → HCID 59540668, compound

Participants

Reaction Steps

A solution of 4-{3-[7-(2,2-Dimethyl-propionyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester (0.1226 g, 0.206 mmol) in 4 mL of hexafluoroisopropanol was stirred at 150° C. for 1 h under microwave irradiation. The reaction mixture was concentrated in vacuo. Silica gel chromatography (0→40% 60:10:1 CH2Cl2:MeOH:NH4OH/dichloromethane over 20 minutes) afforded 0.0704 g (69% yield) of 2,2-Dimethyl-1-[2-(3-piperazin-1-yl-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-one as an off-white solid. MS (E/I): 494 (M+H)

Provenance & Evidence