HCID 44192233, compound → HCID 44193638, compound

HRID 1677421Notes

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]3[N:11]=[C:12]4[C:18]([C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:17][NH:16][C:13]4=[N:14][CH:15]=3)[CH:8]=2)[CH:3]=[CH:2]1.N1C2C(=CC(C3N=C4C(C(=O)C(C)(C)C)=CNC4=NC=3)=CC=2)C=C1>>[NH:1]1[C:9]2[C:8](=[C:7]([C:10]3[N:11]=[C:12]4[C:18]([C:19](=[O:24])[C:20]([CH3:23])([CH3:21])[CH3:22])=[CH:17][NH:16][C:13]4=[N:14][CH:15]=3)[CH:6]=[CH:5][CH:4]=2)[CH:3]=[CH:2]1

Participants

Reactant 2

HCID 44192233HCID 44192233, compound

HCID 44192591HCID 44192591, compound

Product 1

HCID 44193638HCID 44193638, compound

Procedure

Substituting indole 4-boronic acid for 3-(1-pyrrolidino)phenyl boronic acid. MP=257-258 C, (M+H)+=319. 1-[2-(1H-Indol-6-yl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one. Substituting indole 6-boronic acid for 3-(1-pyrrolidino)phenyl boronic acid. MP=>300 C, (M+H)+=319. 1-[2-(1H-Indol-5-yl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one. Substituting 5-indoleboronic acid for 3-(1-pyrrolidino)phenyl boronic acid. MP=296-297 C, (M+H)=319.

Sources & evidence

ORD record: ord-1ff2657757bc4f52a8f77edddbe7cc99
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08008298B2

Reaction notes

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