861554-75-8 → HCID 59540989, compound

HRID 1677434Notes

Reaction equation

HRID 1677434 reaction equation
I[C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([C:11]3[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[C:13]([O:21][CH3:22])[CH:12]=3)[N:9]=2)[N:4]([Si](C(C)C)(C(C)C)C(C)C)[CH:3]=1.[CH3:33][O:34][CH:35]([CH3:40])[CH2:36][CH2:37][CH:38]=[O:39]>>[CH3:33][O:34][CH:35]([CH3:40])[CH2:36][CH2:37][C:38]([C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([C:11]3[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[C:13]([O:21][CH3:22])[CH:12]=3)[N:9]=2)[NH:4][CH:3]=1)=[O:39]

Participants

3

Reactant 2

HCID 22486473861554-75-8HCID 595405257-iodo-5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine

Product 1

HCID 59540989HCID 59540989, compound

Procedure

4-Methoxy-1-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-pentan-1-one was prepared starting from 7-iodo-5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine and 4-methoxy-pentanal (Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen (1919), 52B 1800-12) following general procedures as described in these Examples 66, to afford a brown solid. MP 150-151° C., M+H=400.

Workup

  1. customto afford a brown solid

Sources & evidence

ORD record
ord-8ef61b584edc4ead9a326f6600c094e4
Source dataset
uspto-grants-2011_08
Patent number
US08008298B2

Reaction notes

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