Potassium Carbonate → HCID 59540852, compound

Participants

Reaction Steps

A microwave tube was charged with 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one (146 mg, 0.52 mmol), 3-ethoxybenzeneboronic acid (94 mg, 0.57 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloro-palladium(II) (34 mg, 0.041 mmol), and K2CO3 (179 mg, 1.30 mmol). Dioxane (4 ml) and water (1 ml) were added, and the tube was microwaved at 150° C. for 30 min. The reaction mixture was partitioned between EtOAc/water. The organic layers were collected, dried over MgSO4, filtered, and concentrated giving a dark brown solid. The crude product was purified by preparative thin layer chromatography (70% EtOAc/Hexane) as eluant to provide 120 mg (72%) of 1-[2-(3-ethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one as a yellow solid. MP 195-196° C., M+H=324.

Provenance & Evidence