HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3,5-Dimethoxyphenyl)boronic acid → HCID 59540810, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3,5-Dimethoxyphenyl)boronic acid | HCID 4374257 | — |
| Reactant | 1-(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one | HCID 57829218 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 59540810 | HCID 59540810 | — |
Reaction Steps
1-[2-(3,5-Dimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one was prepared starting from 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one and (3,5-dimethoxyphenyl)boronic acid following general procedures as described in these Examples. Silica gel chromatography using 10-50% EtOAc in hexanes as eluant provided 90 mg (52%) of a yellow solid. MP 206.9-207.7° C., M+H=340.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008298B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-c8d2d84bce9a455dbcb97e72fe5f0171 |
| Source note | uspto-grants-2011_08 |