HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Hydroxyphenyl)boronic acid → HCID 136102036, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Hydroxyphenyl)boronic acid | HCID 2773454 | — |
| Reactant | 1-(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one | HCID 57829218 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 136102036 | HCID 136102036 | — |
Reaction Steps
1-[2-(2-Hydroxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one was prepared starting from 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one and 2-hydroxybenzeneboronic acid following general procedures as described in these Examples. Silica gel chromatography using 5-70% EtOAc in hexanes as eluant gave 53 mg (28%) of a yellow solid. MP 282-283° C., M+H=296.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008298B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-45fc3972881345c8b0435de5200b0380 |
| Source note | uspto-grants-2011_08 |