4-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine → (1-Methyl-cyclohexyl)-[2-(3-morpholin-4-yl-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-methanone

Participants

Role	Name	HCID	Charge
Reactant	4-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine	HCID 4192663	—
Reactant	(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclohexyl)-methanone	HCID 44199730	—
Product	(1-Methyl-cyclohexyl)-[2-(3-morpholin-4-yl-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-methanone	HCID 59540882	—

Reaction Steps

(1-Methyl-cyclohexyl)-[2-(3-morpholin-4-yl-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-methanone was prepared starting from (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclohexyl)-methanone and 4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine following general procedures as described in these Examples. MP 208-209° C., M+H=405.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08008298B2
Source dataset	uspto-grants-2011_08
ORD ID	ord-35f6f97c55ee4596a8b5357f4b50444a
Source note	uspto-grants-2011_08