HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-HYDROXYPROPYL)PHENYLBORONIC ACID → {2-[3-(3-Hydroxy-propyl)-phenyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-(1-methyl-cyclohexyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-HYDROXYPROPYL)PHENYLBORONIC ACID | HCID 3672173 | — |
| Reactant | (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclohexyl)-methanone | HCID 44199730 | — |
| Product | {2-[3-(3-Hydroxy-propyl)-phenyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-(1-methyl-cyclohexyl)-methanone | HCID 59540934 | — |
Reaction Steps
{2-[3-(3-Hydroxy-propyl)-phenyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-(1-methyl-cyclohexyl)-methanone was prepared starting from (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclohexyl)-methanone and 3-(3-hydroxypropyl)phenylboronic acid following general procedures as described in these Examples. MP 80-83° C., M+H=378.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008298B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-0cbfa546244f4cef8f5269ce478d4d64 |
| Source note | uspto-grants-2011_08 |