4-(Dimethylamino)phenylboronic acid → HCID 59540860, compound

HRID 1677462Notes

Reaction equation

HRID 1677462 reaction equation
Br[C:2]1[N:3]=[C:4]2[C:10]([C:11]([C:13]3([CH3:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)=[O:12])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[CH3:20][N:21]([CH3:31])[C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1>>[CH3:20][N:21]([CH3:31])[C:22]1[CH:27]=[CH:26][C:25]([C:2]2[N:3]=[C:4]3[C:10]([C:11]([C:13]4([CH3:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]4)=[O:12])=[CH:9][NH:8][C:5]3=[N:6][CH:7]=2)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 27343444-(Dimethylamino)phenylboronic acidHCID 44199730(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclohexyl)-methanone

Product 1

HCID 59540860HCID 59540860, compound

Procedure

[2-(4-Dimethylamino-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-(1-methyl-cyclohexyl)-methanone was prepared starting from (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclohexyl)-methanone and 4-(dimethylamino)phenylboronic acid following general procedures as described in these Examples. MP 272-274° C., M+H=363.

Sources & evidence

ORD record
ord-8c91fa52d2c64a50ad0b9321f1a07a38
Source dataset
uspto-grants-2011_08
Patent number
US08008298B2

Reaction notes

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