1-Methylcyclopentane-1-carbonyl chloride → (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclopentyl)-methanone

HRID 1677471Notes

Reaction equation

HRID 1677471 reaction equation
[Br:1][C:2]1[N:3]=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[CH3:11][C:12]1([C:17](Cl)=[O:18])[CH2:16][CH2:15][CH2:14][CH2:13]1>>[Br:1][C:2]1[N:3]=[C:4]2[C:10]([C:17]([C:12]3([CH3:11])[CH2:16][CH2:15][CH2:14][CH2:13]3)=[O:18])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 132052761-Methylcyclopentane-1-carbonyl chlorideHCID 250673082-bromo-5H-pyrrolo[2,3-b]pyrazine

Product 1

HCID 44199843(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclopentyl)-methanone

Procedure

(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclopentyl)-methanone was prepared starting from 2-bromo-5H-pyrrolo[2,3-b]pyrazine and 1-methyl-cyclopentanecarbonyl chloride following general procedures as described in these Examples. MP 206.9-207.9° C., M+H=308.

Sources & evidence

ORD record
ord-f81de50373d34fde8c08c0bc14dea859
Source dataset
uspto-grants-2011_08
Patent number
US08008298B2

Reaction notes

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