2-bromo-5H-pyrrolo[2,3-b]pyrazine → (2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1,3-dimethyl-cyclohexyl)-methanone

HRID 1677472Notes

Reaction equation

HRID 1677472 reaction equation
[Br:1][C:2]1[N:3]=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[CH3:11][C:12]1([C:19](Cl)=[O:20])[CH2:17][CH2:16][CH2:15][CH:14]([CH3:18])[CH2:13]1>>[Br:1][C:2]1[N:3]=[C:4]2[C:10]([C:19]([C:12]3([CH3:11])[CH2:17][CH2:16][CH2:15][CH:14]([CH3:18])[CH2:13]3)=[O:20])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 250673082-bromo-5H-pyrrolo[2,3-b]pyrazineHCID 866466891,3-Dimethyl cyclohexanecarbonyl chloride

Product 1

HCID 59540729(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1,3-dimethyl-cyclohexyl)-methanone

Procedure

(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1,3-dimethyl-cyclohexyl)-methanone was prepared starting from 2-bromo-5H-pyrrolo[2,3-b]pyrazine and 1,3-dimethyl cyclohexanecarbonyl chloride (Journal of Organic Chemistry (1951), 16 920-9) following general procedures as described in these Examples. M+H=336.

Sources & evidence

ORD record
ord-e8c22b8dc68042e2bc87acb95f55067b
Source dataset
uspto-grants-2011_08
Patent number
US08008298B2

Reaction notes

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