3,4,5-Trimethoxybenzeneboronic acid → HCID 59540984, compound

HRID 1677473Notes

Reaction equation

HRID 1677473 reaction equation
Br[C:2]1[N:3]=[C:4]2[C:10]([C:11]([C:13]3([CH3:20])[CH2:18][CH2:17][CH2:16][CH:15]([CH3:19])[CH2:14]3)=[O:12])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[CH3:21][O:22][C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[C:27]([O:31][CH3:32])[C:28]=1[O:29][CH3:30]>>[CH3:20][C:13]1([C:11]([C:10]2[C:4]3[C:5](=[N:6][CH:7]=[C:2]([C:25]4[CH:26]=[C:27]([O:31][CH3:32])[C:28]([O:29][CH3:30])=[C:23]([O:22][CH3:21])[CH:24]=4)[N:3]=3)[NH:8][CH:9]=2)=[O:12])[CH2:18][CH2:17][CH2:16][CH:15]([CH3:19])[CH2:14]1

Participants

3

Reactant 2

HCID 27343903,4,5-Trimethoxybenzeneboronic acidHCID 59540729(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1,3-dimethyl-cyclohexyl)-methanone

Product 1

HCID 59540984HCID 59540984, compound

Procedure

(1,3-Dimethyl-cyclohexyl)-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-methanone was prepared starting from (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1,3-dimethyl-cyclohexyl)-methanone and 3,4,5-trimethoxybenzeneboronic acid following general procedures as described in these Examples. MP 229-231° C., M+H=424.

Sources & evidence

ORD record
ord-3ff1f5aa2b6b45908171467a640a60d8
Source dataset
uspto-grants-2011_08
Patent number
US08008298B2

Reaction notes

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