(4-(Morpholin-4-yl)phenyl)boronic acid → HCID 59540835, compound

HRID 1677476Notes

Reaction equation

HRID 1677476 reaction equation
Br[C:2]1[N:3]=[C:4]2[C:10]([C:11]([C:13]3([CH3:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)=[O:12])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[N:20]1([C:26]2[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][CH:27]=2)[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[CH3:19][C:13]1([C:11]([C:10]2[C:4]3[C:5](=[N:6][CH:7]=[C:2]([C:29]4[CH:28]=[CH:27][C:26]([N:20]5[CH2:21][CH2:22][O:23][CH2:24][CH2:25]5)=[CH:31][CH:30]=4)[N:3]=3)[NH:8][CH:9]=2)=[O:12])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 2795359(4-(Morpholin-4-yl)phenyl)boronic acidHCID 44199730(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclohexyl)-methanone

Product 1

HCID 59540835HCID 59540835, compound

Procedure

(1-Methyl-cyclohexyl)-[2-(4-morpholin-4-yl-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-methanone was prepared starting from (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclohexyl)-methanone and 4-morpholin-4-yl-phenylboronic acid following general procedures as described in these Examples. MP 233-235° C., M+H=405.

Sources & evidence

ORD record
ord-39a0464d3e6d48bdb3b9e4010bb1de1b
Source dataset
uspto-grants-2011_08
Patent number
US08008298B2

Reaction notes

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