HRID1677483

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID392871

1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid

C11H19NO4

结构：CC1(C(=O)c2c[nH]c3ncc(-c4cccc(N5CCNCC5)c4)nc23)CCCCC1

HCID59540704

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(C(=O)N2CCN(c3cccc(-c4cnc5[nH]cc(C(=O)C6(C)CCCCC6)c5n4)c3)CC2)CC1

HCID59540970

未命名化合物

PROCEDURE

实验过程

4-(4-{3-[7-(1-Methyl-cyclohexanecarbonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-phenyl}-piperazine-1-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester was prepared starting from (1-methyl-cyclohexyl)-[2-(3-piperazin-1-yl-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-methanone and piperidine-1,4-dicarboxylic acid mono-tert-butyl ester following general procedures as described in these Examples. M+H=615.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2119cd48e40f4a18aa289762acdf542e
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08008298B2
来源说明: uspto-grants-2011_08

反应 SMILES

[CH3:1][C:2]1([C:8]([C:10]2[C:18]3[C:13](=[N:14][CH:15]=[C:16]([C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([N:25]5[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]5)[CH:20]=4)[N:17]=3)[NH:12][CH:11]=2)=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[C:31]([O:35][C:36]([N:38]1[CH2:43][CH2:42][CH:41]([C:44](O)=[O:45])[CH2:40][CH2:39]1)=[O:37])([CH3:34])([CH3:33])[CH3:32]>>[C:31]([O:35][C:36]([N:38]1[CH2:43][CH2:42][CH:41]([C:44]([N:28]2[CH2:29][CH2:30][N:25]([C:21]3[CH:22]=[CH:23][CH:24]=[C:19]([C:16]4[N:17]=[C:18]5[C:10]([C:8]([C:2]6([CH3:1])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]6)=[O:9])=[CH:11][NH:12][C:13]5=[N:14][CH:15]=4)[CH:20]=3)[CH2:26][CH2:27]2)=[O:45])[CH2:40][CH2:39]1)=[O:37])([CH3:34])([CH3:33])[CH3:32]