tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate → 1-{2-[3-(2,7-Diaza-spiro[4.4]non-2-yl)-phenyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-2,2-dimethyl-propan-1-one

Participants

Reaction Steps

1-{2-[3-(2,7-Diaza-spiro[4.4]non-2-yl)-phenyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-2,2-dimethyl-propan-1-one was prepared starting from 1-[2-(3-iodo-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one and 2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester following general procedures as described in these Examples. M+H=404.

Provenance & Evidence