tert-butyl N-((pyrrolidin-3-yl)methyl)carbamate → 1-{2-[3-(3-Aminomethyl-pyrrolidin-1-yl)-phenyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-2,2-dimethyl-propan-1-one

Participants

Reaction Steps

1-{2-[3-(3-Aminomethyl-pyrrolidin-1-yl)-phenyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-2,2-dimethyl-propan-1-one was prepared starting from 1-[2-(3-iodo-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one and pyrrolidin-3-ylmethyl-carbamic acid tert-butyl ester following general procedures as described in these Examples. M+H=378.

Provenance & Evidence