tert-Butyl 2-methylpiperazine-1-carboxylate → HCID 59541042, compound

HRID 1677499Notes

Reaction equation

I[C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]3[C:16]([C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:15][N:14](COCC[Si](C)(C)C)[C:11]3=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.C(OC([N:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH:39]1[CH3:44])=O)(C)(C)C>>[CH3:20][C:18]([CH3:21])([CH3:19])[C:17]([C:16]1[C:10]2[C:11](=[N:12][CH:13]=[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([N:41]4[CH2:42][CH2:43][NH:38][CH:39]([CH3:44])[CH2:40]4)[CH:3]=3)[N:9]=2)[NH:14][CH:15]=1)=[O:22]

Participants

Reactant 2

HCID 15087784tert-Butyl 2-methylpiperazine-1-carboxylate

HCID 595405201-[2-(3-iodo-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one

Product 1

HCID 59541042HCID 59541042, compound

Procedure

2,2-Dimethyl-1-{2-[3-(3-methyl-piperazin-1-yl)-phenyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-propan-1-one was prepared starting from 1-[2-(3-iodo-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one and 2-methyl-piperazine-1-carboxylic acid tert-butyl ester following general procedures as described in these Examples. M+H=378.

Sources & evidence

ORD record: ord-626d6accc37645a083c18ef45fe1cc9d
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08008298B2

Reaction notes

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