HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67346423, compound → HCID 59540622, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67346423 | HCID 67346423 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 59540622 | HCID 59540622 | 83% |
Reaction Steps
3-[7-(2,2-Dimethyl-propionyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-N-(2-hydroxy-ethyl)-5-pyrrolidin-1-yl-benzamide was prepared following the same procedure but using 3-[7-(2,2-dimethyl-propionyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-N-(2-hydroxy-ethyl)-5-pyrrolidin-1-yl-benzamide as starting material. The product was obtained in 83% yield after SiO2 chromatography (DCM/MeOH 0-5% MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008298B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-053c147816f94cbcb26160171165a727 |
| Source note | uspto-grants-2011_08 |