m-Chloroperbenzoic acid → HCID 59540743, compound

Participants

Reaction Steps

To a flask was added 2,2-Dimethyl-1-[2-(3-thiomorpholin-4-yl-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-one (prepared using general procedures described in these Examples) 0.030 gm (0.059 mM), 3-chloroperbenzoic acid (77%) 0.015 gm (0.067 mM), dichloromethane, stirred over night, rinsed with saturated aqueous sodium bicarbonate and purified on preparative TLC plate (3:1 ethyl acetate/hexane) tog give 0.019 gm (0.036 mM, 61% yield) of the sulfoxide. The SEM protecting group was removed following general procedures as described in these Examples to give 2,2-Dimethyl-1-{2-[3-(1-oxo-1lambda*4*-thiomorpholin-4-yl)-phenyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-propan-1-one, 0.0025 gm, (0.006 mM) M+1 397.

Provenance & Evidence