m-Chloroperbenzoic acid → HCID 59540903, compound

Participants

Reaction Steps

To a solution of 1-[2-(3-methoxy-5-thiomorpholin-4-yl-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one (80 mg, 0.195 mmol) in methylene chloride (5 ml) and methanol (5 drops) was added m-CPBA (44 mg, 0.195 mmol). After 1 hour the crude material was loaded onto 2 preparative TLC plates, eluting with 10% methanol in methylene chloride. The product band was collected to afford 61 mg of 1-{2-[3-methoxy-5-(1-oxo-1lambda*4*-thiomorpholin-4-yl)-phenyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-2,2-dimethyl-propan-1-one as a light yellow-brown solid. MP 259-260° C., M+H=427.

Provenance & Evidence