Potassium Carbonate → HCID 59540678, compound

Participants

Reaction Steps

2,2-Dimethyl-1-[2-(3-trimethylsilanyl-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-one (250 mg, 0.71 mmol) was suspended in 7 ml of methylene chloride and potassium carbonate (393 mg, 2.8 mmol) was added. The flask was wrapped in aluminum foil and iodine monochloride (2.5 ml of a 1M solution in methylene chloride) was added dropwise. The mixture was stirred in the dark at room temperature for one hour. The reaction was quenched with 10% aqueous sodium thiosulfate, extracted into methylene chloride, and washed with water two times. The organic layer was dried with sodium sulfate, concentrated, triturated with ethyl ether, filtered and dried in a vacuum oven to give 232 mg (81%) of 1-[2-(3-iodo-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2,-dimethyl-propan-1-one as a yellow solid. (M+H)+=406.

Provenance & Evidence