Lithium Hydroxide → HCID 86629246, compound

Participants

Reaction Steps

To a slurry of 2-(3-(N,N′-di(t-butoxycarbonyl)guanidino)phenyl)-2-((1-(benzyloxycarbonyl)amino-2-methylpropyl)(hydroxy)phosphinoyloxy)ethanoic acid methyl ester in 10 mL of MeOH and 5 mL of H2O was added LiOH (411.9 mg, 9.82 mmol). After stirring the cloudy yellow solution for 2 hours, the reaction was acidified to pH 2 with 1M NaHSO4 and extracted with CH2Cl2 (3×). The combined organic layers were dried over MgSO4, filtered, and concentrated in vacuo to give 2-(3-(N,N′-di(t-butoxycarbonyl)guanidino)phenyl)-2-((1-(benzyloxycarbonyl)amino-2-methylpropyl)-(hydroxy)phosphinoyloxy)ethanoic acid as a yellow oil that was used without further purification.

Provenance & Evidence